U24AG074855

Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium - Abstract

In response to PAR-20-099 "Harmonization of Alzheimer's Disease and Related Dementias (AD/RD) Genetic, Epidemiologic, and Clinical Data to Enhance Therapeutic Target Discovery," we have assembled a multidisciplinary team that includes experts in neuroimaging, neuropsychology, fluid biomarkers, neuropathology, and vascular contributions to ADRD. Our ADSP Phenotype Harmonization Consortium, or "ADSP-PHC," seeks to work in coordination with existing ADSP workgroups and initiatives to streamline access to endophenotype data, provide high-quality endophenotype harmonization across multiple research domains, and provide comprehensive documentation of both data availability and harmonization procedures.

This project includes two coordinating centers, three cores, and eight domain-specific harmonization teams led by world-renowned experts in their fields. While our efforts will focus on data access, documentation, and harmonization, we will work closely with other ADSP workgroups and other large-scale harmonization efforts to maximize the impact and align with NIH priorities. In particular, we will focus harmonization on ADRD-related endophenotypes, including cognitive scores derived from detailed neuropsychological assessments, measures of neuropathology measured both ex vivo (neuropathological assessment at autopsy) and in vivo (fluid biomarkers and positron emission tomography biomarkers), concomitant pathways of injury (vascular risk factors and vascular brain injury), and measures of neurodegeneration focusing on both white (diffusion-weighted MRI) and grey matter (T1-weighted MRI).

The proposed harmonization effort will provide an unprecedented opportunity to disentangle the genetic architecture of individual biological contributors to ADRD risk and progression. The harmonized data, protocols, and educational tools developed by the ADSP-PHC will transform the ADRD landscape, accelerate discovery, and facilitate the application of emerging big data analytic approaches leveraging machine learning and artificial intelligence.

Vanderbilt University Medical Center

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Nashville, Tennessee 37203 United States

Single Zip Code

Harmonization of Alzheimers Disease and Related Dementias (AD/ADRD) Genetic, Epidemiologic, and Clinical Data to Enhance Therapeutic Target Discovery (U24 Clinical Trial Not Allowed) (PAR-20-099)

Amendment Since initial award the total obligations have increased 326% from $6,835,050 to $29,127,266.