P50MH127511

Penn Innovation in Suicide Prevention Implementation Research (INSPIRE) Center - This proposal is to develop the University of Pennsylvania's Innovation in Suicide Prevention Implementation Research (INSPIRE) Center. Suicide is a leading cause of death in the US that disproportionately affects minority and disenfranchised populations, including Blacks, Hispanics, and sexual/gender minorities. Yet, these groups often are not included in suicide prevention research.

Guided by a conceptual model based on the Integrated Behavior Model, which posits that organizational culture, policies, and resources (or lack thereof) impact the provider's attributes and behaviors, INSPIRE brings together psychology, implementation science, health economics, machine learning, health information technology, psychiatry, and participatory research experts to apply innovative interdisciplinary approaches to suicide prevention.

INSPIRE's overarching goals are to develop and adapt practice-based and other suicide prevention interventions for underserved groups and to design and test implementation strategies to optimize how evidence-based practices can be brought to scale efficiently and with high fidelity, for optimal effectiveness. INSPIRE will prioritize strategies that can be rapidly deployed in a range of practice settings, including those with limited resources, thereby increasing their reach and public health impact.

Penn INSPIRE will use state-of-the-science methods from participatory research to actively engage stakeholders from many sectors – including patients, providers, and payers – at every level of its work to accomplish its specific aims. INSPIRE will apply innovative, interdisciplinary behavior change and implementation science methods to develop, adapt, and evaluate cost-effective interventions.

A signature project will use a stepped wedge study design to test an innovative organizational strategy that leverages telehealth to deliver high-quality safety planning intervention and follow-up services in emergency departments. Three exploratory projects will test novel strategies for suicide prevention across individual, clinician, and organizational levels and with specific vulnerable populations that will lay the foundation for more definitive studies.

INSPIRE will also support 10 pilot projects and an innovative methods core that will develop and test new methods to advance research at the intersection of suicide prevention and implementation science. The Suicide Prevention Scholars Program will expand the cadre of suicide prevention researchers by engaging both emerging investigators and established scientists who do not currently work on suicide prevention – particularly those from groups underrepresented in research – through content, design, and methodological mentoring and capacity-building.

By catalyzing interdisciplinary, cross-sector collaborations and advancing suicide prevention research, care, and policy both locally and nationally, we will develop cost-effective, practical, and efficient ways to implement evidence-based suicide prevention interventions. INSPIRE is poised to be transformational for suicide prevention.

Trustees Of The University Of Pennsylvania

THE MISSION OF THE NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) IS TO TRANSFORM THE UNDERSTANDING AND TREATMENT OF MENTAL ILLNESSES THROUGH BASIC AND CLINICAL RESEARCH, PAVING THE WAY FOR PREVENTION, RECOVERY, AND CURE. IN MAY 2020, NIMH RELEASED ITS NEW STRATEGIC PLAN FOR RESEARCH. THE NEW STRATEGIC PLAN BUILDS ON THE SUCCESSES OF PREVIOUS NIMH STRATEGIC PLANS BY PROVIDING A FRAMEWORK FOR SCIENTIFIC RESEARCH AND EXPLORATION, AND ADDRESSING NEW CHALLENGES IN MENTAL HEALTH. THE NEW STRATEGIC PLAN OUTLINES FOUR HIGH-LEVEL GOALS: GOAL 1: DEFINE THE BRAIN MECHANISMS UNDERLYING COMPLEX BEHAVIORS GOAL 2: EXAMINE MENTAL ILLNESS TRAJECTORIES ACROSS THE LIFESPAN GOAL 3: STRIVE FOR PREVENTION AND CURES GOAL 4: STRENGTHEN THE PUBLIC HEALTH IMPACT OF NIMH-SUPPORTED RESEARCH THESE FOUR GOALS FORM A BROAD ROADMAP FOR THE INSTITUTE'S RESEARCH PRIORITIES OVER THE NEXT FIVE YEARS, BEGINNING WITH THE FUNDAMENTAL SCIENCE OF THE BRAIN AND BEHAVIOR, AND EXTENDING THROUGH EVIDENCE-BASED SERVICES THAT IMPROVE PUBLIC HEALTH OUTCOMES. THE INSTITUTE'S OVERALL FUNDING STRATEGY IS TO SUPPORT A BROAD SPECTRUM OF INVESTIGATOR-INITIATED RESEARCH IN FUNDAMENTAL SCIENCE, WITH INCREASING USE OF INSTITUTE-SOLICITED INITIATIVES FOR APPLIED RESEARCH WHERE PUBLIC HEALTH IMPACT IS A SHORT-TERM MEASURE OF SUCCESS. THE NEW STRATEGIC PLAN ALSO ADDRESSES A NUMBER OF CROSS-CUTTING THEMES THAT ARE RELEVANT TO ALL RESEARCH SUPPORTED BY NIMH, THESE THEMES HIGHLIGHT AREAS WHERE NIMH-FUNDED SCIENCE MAY HAVE THE GREATEST IMPACT, BRIDGE GAPS, AND OFFER NOVEL APPROACHES TO ACCELERATE ADVANCES IN MENTAL HEALTH RESEARCH. FOR EXAMPLE, NIMH VALUES A COMPREHENSIVE RESEARCH AGENDA THAT TAKES AN INCLUSIVE APPROACH THAT ENSURES RESEARCH INTERESTS ARE VARIED, MAINTAIN DIVERSE PARTICIPATION AND PARTNERSHIPS, AND ACHIEVE RESEARCH GOALS ACROSS MULTIPLE TIMEFRAMES. THIS INCLUDES DIVERSE METHODOLOGIES, TOOLS, AND MODELS, RESEARCH ADDRESSING COMPLEX BASIC, TRANSLATIONAL, AND APPLIED QUESTIONS, RESEARCH INCLUDING BOTH SEXES AND, AS APPROPRIATE, GENETIC BACKGROUND, AND, PARTICIPANTS FROM DIVERSE RACIAL AND ETHNIC BACKGROUNDS, AND ACROSS GENDER IDENTITIES, GEOGRAPHICAL CONTEXT, SOCIOECONOMIC STATUS, NEUROTYPE, AND AGE OFFERING THE BEST POSSIBLE REPRESENTATION, FOR THE BROADEST NUMBER OF INDIVIDUALS WHO MAY ULTIMATELY BENEFIT FROM THESE SCIENTIFIC ADVANCES. TO ACCOMPLISH THE GOALS OUTLINED IN THE NEW STRATEGIC PLAN, NIMH WILL SUPPORT RESEARCH THAT AIMS: TO CHARACTERIZE THE GENOMIC, MOLECULAR, CELLULAR, AND CIRCUIT COMPONENTS CONTRIBUTING TO BRAIN ORGANIZATION AND FUNCTION, TO IDENTIFY THE DEVELOPMENTAL, FUNCTIONAL, AND REGULATORY MECHANISMS RELEVANT TO COGNITIVE, AFFECTIVE, AND SOCIAL DOMAINS, ACROSS UNITS OF ANALYSIS, AND, TO GENERATE AND VALIDATE NOVEL TOOLS, TECHNIQUES, AND MEASURES TO QUANTIFY CHANGES IN THE ACTIVITY OF MOLECULES, CELLS, CIRCUITS, AND CONNECTOMES. TO DISCOVER GENE VARIANTS AND OTHER GENOMIC ELEMENTS THAT CONTRIBUTE TO THE DEVELOPMENT OF MENTAL ILLNESSES IN DIVERSE POPULATIONS, TO ADVANCE OUR

93.242 - Mental Health Research Grants

National Institute of Mental Health (NIMH) [HHS - NIH]

Philadelphia, Pennsylvania 191043317 United States

Single Zip Code

Practice-Based Suicide Prevention Research Centers (P50 Clinical Trial Optional) (PAR-20-286)

Amendment Since initial award the total obligations have increased 283% from $3,074,419 to $11,789,522.