Scaling-up and Maintaining Evidence-based Interventions to Maximize Impact on Cancer (SUMMIT)- Lung Cancer Screening (UG3/UH3 Clinical Trial Required)

Background
The National Cancer Institute (NCI), part of the Department of Health and Human Services, aims to advance the science of scaling up and sustaining lung cancer screening (LCS) for populations at high risk for lung cancer.

This funding opportunity seeks to support research projects that will identify effective implementation strategies for delivering LCS across diverse clinical settings, particularly focusing on populations experiencing health inequities.

Grant Details
This Notice of Funding Opportunity (NOFO) invites proposals for Research Projects aimed at advancing the science of scale-up and sustainment of lung cancer screening (LCS). Each project must propose a randomized controlled trial design to test implementation strategies that equitably and effectively scale-up LCS delivery.

Key tasks include: conducting trials at a minimum of 60 diverse sites, focusing on all essential processes of LCS, measuring service delivery at least 12 months post-implementation, and utilizing validated measures aligned with the SUMMIT Initiative.

The UG3 phase will support preparatory activities while the UH3 phase will focus on conducting the trial.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, tribal governments, and other entities. Institutions are encouraged to include diverse perspectives in their teams. Only one application per institution is allowed.

Period of Performance
The grant has a maximum project period of two years for the UG3 phase and four years for the UH3 phase.

Grant Value
NCI intends to commit $2,400,000 to fund up to 3 awards in FY 2025. Application budgets may not exceed $500,000 in direct costs per year for the UG3 phase and $850,000 in direct costs per year for the UH3 phase.

Place of Performance
The grant activities will be performed across various clinical care settings in the United States.