Optimizing Natural Systems for Remediation: Utilizing Innovative Materials Science Approaches to Enhance Bioremediation (R01 Clinical Trial Not Allowed)

The National Institute of Environmental Health Sciences (NIEHS) invites qualified investigators from domestic institutions of higher education to submit an application for Superfund Research Program (SRP) R01 Individual Research Project grant program. This Funding Opportunity Announcement (FOA) focuses on research that will advance effectiveness of bioremediation through incorporation of advanced, novel materials science approaches. Bioremediation refers to the use of biota (bacteria, algae, fungi, plants, etc.) to reduce or detoxify hazardous substances in the environment. Bioremediation is a cost-effective, low-energy-intensive remedy that has contributed to the cleanup and closure of sites impacted by hazardous substances. In recent decades, bioremediation has advanced from reliance upon culturing and biogeochemical processing to a technology-enabled field enhanced by high throughput molecular approaches (e.g. omics and gene editing techniques). These new approaches have elucidated molecular mechanisms responsible for contaminant cleanup and provided insight for potential solutions to naturally degrade emerging contaminants. Concurrent advances in materials science approaches present an opportunity to integrate new approaches to further refine the mechanisms of bioremediation and optimize conditions to accelerate natural degradation and/or stabilization processes. This Funding Opportunity Announcement calls for teams including bioremediation materials science (nanotechnology, microenvironmental engineering) to submit proposals to advance the knowledge and practice of bioremediation to address current and emerging recalcitrant hazardous substances and complex mixtures.