Halting Tuberculosis (TB) Transmission (R01 Clinical Trial Optional)

Background
The purpose of this notice of funding opportunity (NOFO) is to understand the critical drivers of tuberculosis (TB) transmission at the individual and population levels in high-burden settings; to develop effective methods to measure rates of TB transmission that rely on an increased understanding of the biomedical basis of transmission and related risk factors; and assess potential interventions, including low-cost and low-tech options, to prevent TB transmission and detect infectious TB.

Grant Details
Tuberculosis (TB) is one of the leading infectious disease causes of mortality in the world. The World Health Organization (WHO) estimated that TB claimed the lives of 1.3 million people in the previous year, including 167,000 people co-infected with HIV. The key drivers of transmission are not completely understood. Recent evidence suggests that individuals with subclinical and asymptomatic TB may be a significant source of transmission. More evidence is needed to determine their contribution to transmission as this could inform treatment options.

Areas of interest include understanding the impact of the spectrum of TB disease, aerobiology, environmental impacts on transmission, non-traditional spread, development or assessment of new methods or tools to measure transmission, identifying host factors or host/pathogen interactions that encourage transmission, defining characteristics or sub-populations of Mtb strains that impact transmission, studies of transmission in high-risk groups, understanding the impact of HIV coinfection and antiretroviral therapy on transmission of TB, studies to understand the impact of co-morbidities on TB transmission, and studies to understand how to most effectively utilize resources to reduce transmission.

Eligibility Requirements
Eligible organizations include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, federal governments, U.S. Territory or Possession entities, independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), faith-based or community-based organizations, regional organizations, and non-domestic (non-U.S.) entities (Foreign Organizations). Foreign Organizations are eligible to apply.

Period of Performance
The project period can be up to 5 years. The open date for submission is November 04, 2024. The earliest start date is December 04, 2024.

Grant Value
NIAID intends to commit $6,000,000 in FY 2025 to fund 4-5 awards. Application budgets are not expected to exceed $750,000 in direct costs per year.