Search Grant Opportunities

Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)

ID: PAR-25-038 • Type: Posted

Description

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high-confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular, and circuit substrates of neural function. For the purposes of this NOFO, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular, and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). This can include the fundamental biology of these factors, components, and processes. The resulting paradigms, component pathways, and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. The present NOFO (R01 activity code) can be used for applications to further develop lines of inquiry where feasibility or proof-of-concept has been established. Applicants proposing exploratory research at the early and conceptual stages of project development should apply to the companion R21 NOFO PAR-24-025
Background
The National Institutes of Health (NIH), specifically the National Institute of Mental Health (NIMH), is issuing this Notice of Funding Opportunity (NOFO) to encourage research on high-confidence risk factors associated with complex brain disorders. These disorders include schizophrenia, bipolar disorder, major depression, anxiety disorders, tic disorders, and autism. They impose significant burdens on care and productivity in the U.S. Despite recent advances in identifying genetic variants linked to these conditions, understanding their biological underpinnings remains limited. This NOFO aims to leverage novel technologies to explore the intracellular, transcellular, and circuit substrates of neural function in relation to these disorders.

Grant Details
The NOFO encourages studies that focus on elucidating the neurobiological impacts of individual or combined risk factors related to complex brain disorders. Research may be hypothesis-generating or hypothesis-testing and can utilize various experimental paradigms including in vivo, in situ, or in vitro approaches. Key objectives include:

- Investigating the fundamental biology of high-confidence risk factors.
- Disseminating findings to enrich data resources like Gene Ontology and FAIR Data Informatics.
- Utilizing advanced methodologies such as CRISPR/Cas9 for functional analysis of genes associated with disease risk.
- Exploring mechanisms by which environmental factors interact with genetic risks.
- Developing new biological tools for studying brain signaling relevant to these disorders.

Eligibility Requirements
Eligible applicants include higher education institutions (public and private), nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), local/state governments, tribal governments, federal agencies, and foreign organizations. Individuals from diverse backgrounds are encouraged to apply.

Period of Performance
The maximum project period is 5 years. Specific timelines will depend on the scope of the proposed project.

Grant Value
Application budgets are not limited but must reflect the actual needs of the proposed project. The number of awards will depend on NIH appropriations and the quality of applications received.

Place of Performance
The grant can be performed at eligible institutions worldwide; specific geographic locations are not restricted.
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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Grant
Grant Program (CFDA)
93.242 - Mental Health Research Grants
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 11/18/24 the National Institutes of Health posted grant opportunity PAR-25-038 for Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed). The grant will be issued under grant program 93.242 Mental Health Research Grants.

Timing

Posted Date
Nov. 18, 2024, 12:00 a.m. EST
Closing Date
Sept. 7, 2026, 12:00 a.m. EDT Due in 619 Days
Last Updated
Nov. 18, 2024, 1:27 p.m. EST
Version
1
Archive Date
Oct. 13, 2026

Eligibility

Eligible Applicants
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
Special district governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Public housing authorities/Indian housing authorities
Independent school districts
Private institutions of higher education
County governments
City or township governments
Small businesses
Additional Info
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Contacts

Contact
National Institutes of Health
Contact Email
grantsinfo@nih.gov
Email Description
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Contact Phone
(301) 402-2541
Additional Information
https://grants.nih.gov/grants/guide/pa-files/PAR-25-038.html
Additional Information Site
http://grants.nih.gov/grants/guide/pa-files/PAR-25-038.html

Documents

Posted documents for PAR-25-038

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